Issue 1 - The API key did not setup properly, resulting in a message stating that the system could not access ConnectWise Manage Members
To resolve, delete the current API key and make a new one. Copy the new Private and Public keys to the portal, save and try the connection test again. If this does not work, then check the security permissions in the next solution.
Issue 2 - The security privileges are not proper for the API member. ConnectWise Inc. recommends using "Admin" security role for all Integrations.
Once corrected, the API connection should now connect.